Serious overdosage may perhaps lead to coma, areflexia, cardiorespiratory depression and apnea. The results of overdosage could be managed with benzodiazepine antagonist flumazenil.

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The point out of Ohio utilised midazolam within the execution of Dennis McGuire in January 2014; it took McGuire 24 minutes to die after the method started out, and he gasped and gave the impression to be choking in the course of that time, leading to questions on the dosing and timing of the drug administration, in addition to the selection of medicine.[85]

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In 2011, the ecu Medicines Agency (EMA) granted a advertising authorisation for any buccal application form of midazolam, offered under the brand name title Buccolam. Buccolam was originally approved with the procedure of extended, acute, convulsive seizures in men and women from 3 months to under eighteen a long time of age.

Midazolam incorporates a hazard for abuse and addiction, which can cause overdose and Dying. Taking this medication with alcohol or other medicine that could cause drowsiness or respiratory issues (Specially opioid medications which include codeine, hydrocodone) might induce extremely significant Unwanted effects, together with Demise. To decrease your hazard, your doctor must have you go ahead and take smallest dose of midazolam that actually works, and consider it to the shortest feasible time.

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Midazolam can gradual or halt your breathing, particularly when you've not too long ago utilised an opioid medication or Liquor. Somebody caring for you ought to look for crisis clinical attention In case you have sluggish respiration with lengthy pauses, blue coloured lips, or When you are difficult to wake up.

Midazolam is sometimes used in neonatal intense treatment models. When used, added caution is necessary in newborns; midazolam should not be used for for a longer period than 72 hrs because of hazards of tachyphylaxis, and the opportunity of enhancement of the benzodiazepine withdrawal syndrome, and neurological complications.

[eighty two] Midazolam functions like a sedative but will fall short to render the condemned prisoner unconscious, at which period vecuronium bromide and potassium chloride are administered, stopping the prisoner's respiration and heart, respectively. Considering that the condemned prisoner is just not rendered unconscious but is just sedated, the administration of vecuronium bromide and potassium chloride could potentially cause Excessive ache and panic in the individual staying executed.[83]

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Midazolam is injected into check here a muscle mass or into a vein. A healthcare supplier provides you with this injection.